Transition of Chaotic Flow in a Radially Heated Taylor-Couette System

Numerical simulations have been performed to study the stability of heated, incompressible Taylor-Couette flow for a radius ratio of 0.7 and a Prandtl number of 0.7. As Gr is increased, the Taylor cell that has the same direction of circulation as the natural convection current increases in size and the counterrotating cell becomes smaller. The flow remains axisymmetric and the average heat transfer decreases with the increase in Gr. When the cylinder is impulsively heated, the counterrotating cell vanishes and n = 1 spiral is formed for Gr = 1000. This transition marks an increase in the heat transfer due to an increase in the radial velocity component of the fluid. By slowly varying the Grashof number, the simulations demonstrate the existence of a hysteresis loop. Two different stable states with same heat transfer are found to exist at the same Grashof number. A time-delay analysis of the radial velocity and the local heat transfer coefficient time is performed to determine the dimension at two Grashof numbers. For a fixed Reynolds number of 100, the two-dimensional projection of the reconstructed attractor shows a limit cycle for Gr = −1700. The limit cycle behavior disappears at Gr = −2100, and the reconstructed attractor becomes irregular. The attractor dimension increases to about 3.2 from a value of 1 for the limit cycle case; similar values were determined for both the local heat transfer and the local radial velocity, indicating that the dynamics of the temperature variations can be inferred from that of the velocity variations

Numerical Simulations of Heat Transfer in Taylor-Couette Flow

Numerical simulations have been performed to study the effects of the gravitational and the centrifugal potentials on the stability of heated, incompressible Taylor-Couette flow. The flow is confined between two differentially heated, concentric cylinders, and the inner cylinder is allowed to rotate. The Navier-Stokes equations and the coupled energy equation are solved using a spectral method. To validate the code, comparisons are made with existing linear stability analysis and with experiments. The code is used to calculate the local and average heat transfer coefficients for a fixed Reynolds number (Re = 100) and a range of Grashof numbers. The investigation is primarily restricted to radius ratios 0.5 and 0.7 for fluids with Prandtl number of about 0.7. The variation of the local coefficients of heat transfer on the cylinder surface is investigated, and maps showing different stable states of the flow are presented. Results are also presented in terms of the equivalent conductivity, and show that heat transfer decreases with Grashof number in axisymmetric Taylor vortex flow regime, and increases with Grashof number after the flow becomes nonaxisymmetric

Adverse drug reaction due to combination of gabapentin and nortriptyline along with its causality assessment

The combination of gabapentin and nortriptyline is used as the first line drug treatment for management of neuropathic pain; however adverse drug reactions (ADRs) are one of the main causes for discontinuation of the therapy. This is a case study of erythematous maculopapular rash induced by combination of gabapentin and nortriptyline along with its causality assessment. A 55-year-old female came with complaint of back pain for 1 month. She was diagnosed as a case of L1 acute osteoporotic disc compression fracture. The patient was then administered combination tablet of gabapentin and nortriptyline (100 mg/10 mg) orally for the neuropathic pain. After 3 days she developed erythematous maculopapular rash on face, upper limbs and back. Following this the drug was then discontinued and pheniramine, hydrocortisone and combination tablet of levocetirizine and montelukast was administered to treat the rashes. Causality assessment was done using the Naranjo scale and WHO UMC assessment scale.  The ADRs was reported by VigiFlow in the pharmacovigilance centre. Causality assessment using Naranjo scale (Score 6) and WHO UMC scale indicates probable relationship. Hence, monitoring is essential for any ADRs while using combination of gabapentin and nortriptyline therapy. In case of ADRs, discontinue the therapy and report the adverse drug reactions to pharmacovigilance centre

Examination of aerosol distributions and radiative effects over the Bay of Bengal and the Arabian Sea region during ICARB using satellite data and a general circulation model

In this paper we analyse aerosol loading and its direct radiative effects over the Bay of Bengal (BoB) and Arabian Sea (AS) regions for the Integrated Campaign on Aerosols, gases and Radiation Budget (ICARB) undertaken during 2006, using satellite data from the MODerate Resolution Imaging Spectroradiometer (MODIS) on board the Terra and Aqua satellites, the Aerosol Index from the Ozone Monitoring Instrument (OMI) on board the Aura satellite, and the European-Community Hamburg (ECHAM5.5) general circulation model extended by Hamburg Aerosol Module (HAM). By statistically comparing with large-scale satellite data sets, we firstly show that the aerosol properties measured during the ship-based ICARB campaign and simulated by the model are representative for the BoB and AS regions and the pre-monsoon season. In a second step, the modelled aerosol distributions were evaluated by a comparison with the measurements from the ship-based sunphotometer, and the satellite retrievals during ICARB. It is found that the model broadly reproduces the observed spatial and temporal variability in aerosol optical depth (AOD) over BoB and AS regions. However, AOD was systematically underestimated during high-pollution episodes, especially in the BoB leg. We show that this underprediction of AOD is mostly because of the deficiencies in the coarse mode, where the model shows that dust is the dominant component. The analysis of dust AOD along with the OMI Aerosol Index indicate that missing dust transport that results from too low dust emission fluxes over the Thar Desert region in the model caused this deficiency. Thirdly, we analysed the spatio-temporal variability of AOD comparing the ship-based observations to the large-scale satellite observations and simulations. It was found that most of the variability along the track was from geographical patterns, with a minor influence by single events. Aerosol fields were homogeneous enough to yield a good statistical agreement between satellite data at a 1° spatial, but only twice-daily temporal resolution, and the ship-based sunphotometer data at a much finer spatial, but daily-average temporal resolution. Examination of the satellite data further showed that the year 2006 is representative for the five-year period for which satellite data were available. Finally, we estimated the clear-sky solar direct aerosol radiative forcing (DARF). We found that the cruise represents well the regional-seasonal mean forcings. Constraining simulated forcings using the observed AOD distributions yields a robust estimate of regional-seasonal mean DARF of −8.6, −21.4 and +12.9 W m<sup>−2</sup> at the top of the atmosphere (TOA), at the surface (SUR) and in the atmosphere (ATM), respectively, for the BoB region, and over the AS, of, −6.8, −12.8, and +6 W m<sup>−2</sup> at TOA, SUR, and ATM, respectively

CoMeT: An Integrated Interval Thermal Simulation Toolchain for 2D, 2.5 D, and 3D Processor-Memory Systems

Processing cores and the accompanying main memory working in tandem enable the modern processors. Dissipating heat produced from computation, memory access remains a significant problem for processors. Therefore, processor thermal management continues to be an active research topic. Most thermal management research takes place using simulations, given the challenges of measuring temperature in real processors. Since core and memory are fabricated on separate packages in most existing processors, with the memory having lower power densities, thermal management research in processors has primarily focused on the cores. Memory bandwidth limitations associated with 2D processors lead to high-density 2.5D and 3D packaging technology. 2.5D packaging places cores and memory on the same package. 3D packaging technology takes it further by stacking layers of memory on the top of cores themselves. Such packagings significantly increase the power density, making processors prone to heating. Therefore, mitigating thermal issues in high-density processors (packaged with stacked memory) becomes an even more pressing problem. However, given the lack of thermal modeling for memories in existing interval thermal simulation toolchains, they are unsuitable for studying thermal management for high-density processors. To address this issue, we present CoMeT, the first integrated Core and Memory interval Thermal simulation toolchain. CoMeT comprehensively supports thermal simulation of high- and low-density processors corresponding to four different core-memory configurations - off-chip DDR memory, off-chip 3D memory, 2.5D, and 3D. CoMeT supports several novel features that facilitate overlying system research. Compared to an equivalent state-of-the-art core-only toolchain, CoMeT adds only a ~5% simulation-time overhead. The source code of CoMeT has been made open for public use under the MIT license.Comment: https://github.com/marg-tools/CoMe

Bacillus subtilis natto: a non-toxic source of poly-γ-glutamic acid that could be used as a cryoprotectant for probiotic bacteria

It is common practice to freeze dry probiotic bacteria to improve their shelf life. However, the freeze drying process itself can be detrimental to their viability. The viability of probiotics could be maintained if they are administered within a microbially produced biodegradable polymer - poly-γ-glutamic acid (γ-PGA) - matrix. Although the antifreeze activity of γ-PGA is well known, it has not been used for maintaining the viability of probiotic bacteria during freeze drying. The aim of this study was to test the effect of γ-PGA (produced by B. subtilis natto ATCC 15245) on the viability of probiotic bacteria during freeze drying and to test the toxigenic potential of B. subtilis natto. 10% γ-PGA was found to protect Lactobacillus paracasei significantly better than 10% sucrose, whereas it showed comparable cryoprotectant activity to sucrose when it was used to protect Bifidobacterium breve and Bifidobacterium longum. Although γ-PGA is known to be non-toxic, it is crucial to ascertain the toxigenic potential of its source, B. subtilis natto. Presence of six genes that are known to encode for toxins were investigated: three component hemolysin (hbl D/A), three component non-haemolytic enterotoxin (nheB), B. cereus enterotoxin T (bceT), enterotoxin FM (entFM), sphingomyelinase (sph) and phosphatidylcholine-specific phospholipase (piplc). From our investigations, none of these six genes were present in B. subtilis natto. Moreover, haemolytic and lecithinase activities were found to be absent. Our work contributes a biodegradable polymer from a non-toxic source for the cryoprotection of probiotic bacteria, thus improving their survival during the manufacturing process

Transition of Chaotic Flow in a Radially Heated Taylor-Couette System

Numerical simulations have been performed to study the stability of heated, incompressible Taylor-Couette flow for a radius ratio of 0.7 and a Prandtl number of 0.7. As Gr is increased, the Taylor cell that has the same direction of circulation as the natural convection current increases in size and the counterrotating cell becomes smaller. The flow remains axisymmetric and the average heat transfer decreases with the increase in Gr. When the cylinder is impulsively heated, the counterrotating cell vanishes and n = 1 spiral is formed for Gr = 1000. This transition marks an increase in the heat transfer due to an increase in the radial velocity component of the fluid. By slowly varying the Grashof number, the simulations demonstrate the existence of a hysteresis loop. Two different stable states with same heat transfer are found to exist at the same Grashof number. A time-delay analysis of the radial velocity and the local heat transfer coefficient time is performed to determine the dimension at two Grashof numbers. For a fixed Reynolds number of 100, the two-dimensional projection of the reconstructed attractor shows a limit cycle for Gr = −1700. The limit cycle behavior disappears at Gr = −2100, and the reconstructed attractor becomes irregular. The attractor dimension increases to about 3.2 from a value of 1 for the limit cycle case; similar values were determined for both the local heat transfer and the local radial velocity, indicating that the dynamics of the temperature variations can be inferred from that of the velocity variations

Numerical Simulations of Heat Transfer in Taylor-Couette Flow

Numerical simulations have been performed to study the effects of the gravitational and the centrifugal potentials on the stability of heated, incompressible Taylor-Couette flow. The flow is confined between two differentially heated, concentric cylinders, and the inner cylinder is allowed to rotate. The Navier-Stokes equations and the coupled energy equation are solved using a spectral method. To validate the code, comparisons are made with existing linear stability analysis and with experiments. The code is used to calculate the local and average heat transfer coefficients for a fixed Reynolds number (Re = 100) and a range of Grashof numbers. The investigation is primarily restricted to radius ratios 0.5 and 0.7 for fluids with Prandtl number of about 0.7. The variation of the local coefficients of heat transfer on the cylinder surface is investigated, and maps showing different stable states of the flow are presented. Results are also presented in terms of the equivalent conductivity, and show that heat transfer decreases with Grashof number in axisymmetric Taylor vortex flow regime, and increases with Grashof number after the flow becomes nonaxisymmetric